What is Duloxetine

Duloxetine (Cymbalta) is a highly effective treatment for depression, as well as a painful form of diabetic neuropathy. Duloxetine inhibits the reuptake of serotonin and noradrenaline, resulting in increased serotonergic and noradrenergic neurotransmission in the CNS.

Duloxetine indications

  • Treatment of depression
  • Treatment of anxiety disorder
  • Treatment of neuropathic pain associated with diabetes
  • Treatment of chronic musculoskeletal pain
  • Management of fibromyalgia

Duloxetine effectiveness

This modern preparation with proven dual mechanism of action is very effective in the treatment of depression of varying severity. In addition to its high efficiency, Dulexetine has high speed of action. Distinct effect has been observed for the first week of use of Dulexetine.

Dulexetine 20 mg

0.96 $ per pill
  • Dosage form
  • Capsules
  • Dulexetine
  • (Generic Cymbalta)
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Duloxetine 30 mg

1.32 $ Price per month
  • Dosage form
  • Capsules
  • Duloxetine
  • (Generic Cymbalta)
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Duloxetine 40 mg

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1.79 $ Price per month
  • Dosage form
  • Capsules
  • Dulexetine
  • (Generic Cymbalta)
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Consumer information

Study of duloxetine efficacy in the fight against chronic migraine proves that the drug can successfully cope with the pain and increases the pain threshold. Of the 46 patients suffering from chronic migraine, severe improvement occurs in more than half. At the end of this three-month course of treatment the average number of days without headache (within one month) increased by approximately 60%, and the frequency of migraine attacks decreased by 40%.
Duloxetine is administered orally regardless of meal. The capsules should be swallowed whole without chewing or crushing. You can not add in food preparation or mixing it with liquids because it can damage the shell enteric pellets. The recommended initial dose - 60 mg 1 time per day. If necessary, the dose may be increased up to a maximum dosage of 120 mg per day in 2 divided doses. Systematic evaluation of the drug at a dose of more than 120 mg are not carried out. When ESRD (creatinine clearance less than 30 ml/min), the initial dose - 30 mg 1 time per day. Patient having liver failure should reduce the initial dose of the drug or reduce the multiplicity of reception.

Because of insufficient experience with duloxetine during pregnancy, Cymbalta should be used during pregnancy only if the potential benefit to the mother outweighs the potential risk significantly to the fetus. Patients should be warned that in the event or planning a pregnancy during treatment with duloxetine, they should report this to your doctor.

Taking into consideration the lack of experience with duloxetine in women during lactation is not recommended breastfeeding during duloxetine therapy.

Duloxetine statistics

0 bln $ sales in 2013
0 years on US market
0 million customers

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